Nduduzo Makhathini (born 24 September 1982) is a South African jazz musician from Umgungundlovu, Pietermaritzburg, South Africa.

Coming from a musical family, his love for music began at an early age. Makhathini has performed with Zim Ngqawana, Feya Faku, McCoy Mrubata. Nduduzo completed his Diploma in Jazz Piano at Durban University of Technology in 2005. In April 2020, his studio album Modes of Communication: Letters from the Underworld was released.