The Isley Brothers (pron.: /ˈaɪzliː/ yz-lee) are an American musical group consisting of brothers Ron and Ernie Isley. The founding members of the band were Ronald Isley, older brothers Rudy and Kelly and younger brother Vernon. Originally formed as a gospel quartet, following the death of brother Vernon, the remaining trio launched a career into doo-wop scoring with their first million-selling hit single, "Shout", in 1959. Follow-up successes came with the 1962 single, "Twist and Shout" and the 1966 Motown single, "This Old Heart of Mine (Is Weak for You)".

Following the release of their 1969 Grammy Award winning hit, "It's Your Thing" and subsequent other hits on their own label, the family eventually grew to include younger brothers Ernie and Marvin Isley as well as brother-in-law Chris Jasper. From 1973 until 1983, the group would release a successive string of hit albums and singles on the R&B charts, becoming one of the few successful black groups to successfully cross over into the pop charts due to their mixture of soul, funk and rock thanks to the albums, 3 + 3 and The Heat Is On and also helped pioneer the quiet storm format with a string of ballads on their 1970s and 1980s albums. Since then, the group has gone through different lineup changes becoming one of the few acts to have successfully charted a single or an album in five decades. The group has been awarded with accolades including inductions to the Rock & Roll Hall of Fame, the Vocal Group Hall of Fame as well as the R&B Foundation Lifetime Achievement Award.